Velnoryx™
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Prescription epinephrine nasal spray

Velnoryx™(epinephrine) nasal sprayEpinephrine for a severe allergic reaction — no needle

Velnoryx, pronounced VEL nor iks

Velnoryx™ is a single-dose nasal spray that delivers epinephrine, the first-line treatment for anaphylaxis. It fits in a pocket. You spray it into one nostril, then call for emergency help.

See how to use itSavings and coverage
Velnoryx (epinephrine) nasal spray 2 mg, a small single-dose intranasal device with a tapered white nozzle, blue label band, blue finger flanges, and blue plunger base

Velnoryx™ nasal spray — single-dose, non-refillable. Device shown is not actual size.

Two sprays, always

Each device holds one dose. Reactions don't follow rules, so carry two of them wherever you go — school, work, the car, a trip.

Into the nose, not the leg

There's no needle to line up and no skin to press against. Point the tip into one nostril and press.

Small enough to actually carry

It's light and compact, so it can live in a bag or pocket instead of at home in a drawer.

The Velnoryx (epinephrine) nasal spray 2 mg device between a house key and a smartphone, a little longer than the key and just over half the length of the phone

Each device delivers one dose and stands about 3 inches (85 mm) tall — a little over half the length of a phone. Device shown is not actual size.

Small enough to actually carry

It's light and compact, so it can live in a bag, a pocket, a school locker, or a glovebox instead of at home in a drawer. Each device holds a single dose, so carry two wherever you go — a reaction doesn't wait for you to get home.

Use it early, then get help

At the first sign of a severe reaction, use Velnoryx™. If symptoms stay the same or get worse, give a second dose with a new spray in the same nostril, waiting at least 10 minutes between doses. Then get emergency medical care — every time, even if the person feels better.

What to expect after a dose

Epinephrine works fast, and you feel it working. Most of what people notice comes from the medicine doing its job, and it eases off. None of it is a reason to hold back on using Velnoryx™ during a severe reaction.

  • Discomfort inside the nose, congestion, or a runny nose
  • Headache
  • Throat irritation
  • Feeling jittery, nervous, or shaky
  • Nosebleed or sneezing
  • Dizziness
  • Nausea or vomiting
What to expect after a doseFull Important Safety Information

Where to next

How to use it

Step by step, plus storage and shelf life.

About anaphylaxis

Triggers, symptoms, and when to act.

Savings and coverage

Co-pay program, insurance, and delivery.

Doctor discussion guide

Questions worth asking at your visit.

Approval code: VEL-US-12051-02 | 06/2025

Important Safety Information

What should I know about Velnoryx™?

Velnoryx™ contains epinephrine, a medication used to treat life-threatening allergic emergencies (anaphylaxis). Anaphylaxis can occur within minutes and may result from insect stings, allergy shots, certain foods, medications, exercise, or unknown triggers.

Always carry two Velnoryx™ nasal sprays with you since anaphylaxis can be unpredictable, and a second dose may be necessary if symptoms persist or return. Each Velnoryx™ contains a single dose of epinephrine and is designed for intranasal use only.

Use Velnoryx™ immediately at the first sign of an allergic reaction. If symptoms persist or worsen after the initial dose, administer a second dose using a new Velnoryx™ spray in the same nostril, waiting at least 10 minutes between doses. After using Velnoryx™, seek emergency medical attention for further care.

Before using Velnoryx™, inform your healthcare provider if:

  • You have nasal conditions that may affect its use.
  • You have any underlying medical conditions, especially heart problems, high blood pressure, thyroid disorders, Parkinson's disease, diabetes, kidney problems, or low potassium levels in your blood.
  • You are pregnant, planning to become pregnant, or breastfeeding.
  • You take other medications, such as nasal sprays, diuretics, antidepressants, or medicines for heart disease, allergies, or labor. Velnoryx™ may interact with other medications, potentially causing side effects or altering how the medicines work.

What are the potential side effects of Velnoryx™?

Velnoryx™ may cause serious side effects. If you have certain medical conditions or take specific medications, you could experience increased or prolonged side effects.

Common side effects include nasal discomfort, headache, throat irritation, chest or nasal congestion, feelings of nervousness or excitement, nosebleeds, nasal pain, sneezing, runny or dry nose, dry throat, tingling sensations (including in the nose), fatigue, dizziness, nausea, and vomiting.

If you experience side effects that are bothersome or do not resolve, inform your healthcare provider.

This is not a comprehensive list of all possible side effects. For medical advice about side effects, reach out to your healthcare provider. To report side effects, contact NeurovaRx Pharmaceuticals Operations, Inc.

Please see the full Important Safety Information and talk with your healthcare provider.

Important Safety Information

Velnoryx™ contains epinephrine, used to treat life-threatening allergic emergencies (anaphylaxis). Always carry two Velnoryx™ nasal sprays. Use Velnoryx™ immediately at the first sign of an allergic reaction, and seek emergency medical attention after use.

Full Important Safety InformationPrescribing InformationPatient InformationInstructions for Use